checkerboard.rotated.jpg (313426 bytes)

An image of the barrel cortex of a young adult mouse that was stained for synaptic zinc. The animal had the mystacial whiskers on the contralateral face plucked in a checkerboard pattern only 12 hours prior to perfusion and staining. The compartments with increased levels of zinc staining correspond to the plucked whiskers. Thus, levels of synaptic zinc are rapidly modulated in an activity-dependent manner. Contributed by Richard Dyck, University of Calgary. Taken from Brown, CE, and Dyck, RH, "Experience-dependent regulation of synaptic zinc is impaired in the cortex of aged mice", Neuroscience 119(3): 795-801 (2003).

 

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